Key result
Preadult onset of major depressive disorder was associated with higher rates of family history of depression and more past suicide attempts compared to adult onset.
Why the study?
Are clinical characteristics different between preadult onset and adult onset major depressive disorder?
Observational (n=2,541)
Are clinical characteristics different between preadult onset and adult onset major depressive disorder?
Preadult onset MDD is associated with a more familial form of depression and higher suicidality compared to adult onset MDD.
Preadult MDD onset may flag higher chronicity risk; hypothesis-generating for age-specific prognostic models pending prospective validation.
OBJECTIVE: In the first 1500 participants with major depressive disorder (MDD) that entered the sequenced treatment alternatives to relieve depression (STAR*D) study, those with preadult onset MDD were more likely to be women and to have a more chronic, severe and disabling form of depression than those with adult onset MDD. This study seeks to replicate these findings. METHOD: The second wave of STAR*D enrollees included 2541 out-patients with MDD, divided into preadult (before age 18) and adult (age 18 or later) onset groups. RESULTS: Participants with a preadult onset of MDD (38%) were younger, ill for longer and more likely to be women than those with adult onset MDD (62%). After adjusting for age, duration of illness and gender, participants with preadult onset MDD also had higher rates of family history of depression, more past suicide attempts, and lower rates of obsessive compulsive and panic disorder. CONCLUSION: Preadult onset MDD may be associated with a more familial form of depression with more suicidality than adult onset MDD.
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Zisook et al. (2006) conducted an observational in Major depressive disorder (n=2,541). Preadult onset of major depressive disorder vs. Adult onset of major depressive disorder was evaluated on Clinical characteristics including family history of depression and past suicide attempts. Preadult onset of major depressive disorder was associated with higher rates of family history of depression and more past suicide attempts compared to adult onset.
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