Key result
Nitrate supplementation substantially lowers post-exercise SBP and attenuates exercise blood pressure response.
Why the study?
The effect of nitrate supplementation on blood pressure responses during large muscle mass isometric and ischaemic exercise in healthy young adults was unclear.
Does 5-day nitrate supplementation reduce blood pressure responses at rest and during isometric ischaemic exercise in healthy males?
RCT (n=14)
double-blinded
crossover
No
Does 5-day nitrate supplementation reduce blood pressure responses at rest and during isometric ischaemic exercise in healthy males?
Standardized Mean Difference: 1.27 (95% CI 0.17–1.5)
p-value: p=0.006
Five days of high-dose nitrate supplementation effectively attenuates increased blood pressure responses during and after submaximal isometric exercise in healthy males.
Supports nitrate use to blunt BP rises during/after isometric exercise in healthy males; extends low-certainty evidence from 5 prior small trials.
The effect of nitrate (NO3−) supplementation on blood pressure (BP) responses during large muscle mass isometric and ischaemic exercise in healthy young adults is unclear. The aim of the present study was to assess the effect of 5-day supplementation of NO3− on BP responses during a short isometric contraction and a sustained ischaemic contraction. In a randomised, double-blinded, crossover design, 14 healthy active young adults underwent BP measurements after 5 days of either NO3− (NIT) or placebo (PLA) supplementation. Beat-by-beat BP was measured at pre- and post-exercise rest, and during a short (20 s) isometric contraction at 25% maximal strength and throughout a sustained ischaemic contraction. Plasma nitrite (NO2−) concentration increased significantly after NO3− supplementation compared to placebo (475 ± 93 nmol·L−1 vs. 198 ± 46 nmol·L−1, p < 0.001, d = 3.37). Systolic BP was significantly lower at pre- (p = 0.051) and post-exercise rest (p = 0.006), during a short isometric contraction (p = 0.030), and throughout a sustained ischaemic contraction (p = 0.040) after NO3− supplementation. Mean arterial pressure was significantly lower at pre- (p = 0.004) and post-exercise rest (p = 0.043), during a short isometric contraction (p = 0.041), and throughout a sustained ischaemic contraction (p = 0.021) after NO3− supplementation. Diastolic BP was lower at pre-exercise rest (p = 0.032), but not at post-exercise rest, during a short isometric contraction, and during a sustained ischaemic contraction (all p > 0.05). Five days of NO3− supplementation elevated plasma NO2− concentration and reduced BP during a short isometric contraction and a sustained ischaemic contraction in healthy adults. These observations indicate that multiple-day nitrate supplementation can decrease BP at rest and attenuate the increased BP response during isometric exercise. These findings support that NO3− supplementation is an effective nutritional intervention in reducing SBP and MAP in healthy young males during submaximal exercise.
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Esen et al. (2022) conducted an RCT in Healthy active young males (n=14). Nitrate (NO3-) supplementation vs. Placebo was evaluated on Systolic blood pressure at post-exercise rest (d = 1.27, 95% CI 0.17, 1.50, p=0.006). Five days of nitrate supplementation significantly lowered systolic blood pressure at post-exercise rest (d = 1.27) and attenuated the blood pressure response during isometric exercise in healthy males.
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