Key result
In Japanese adults with congenital heart disease, low-dose amiodarone therapy was associated with a 30% incidence of thyroid dysfunction, and liver dysfunction was an independent risk factor for hypothyroidism (HR 2.573).
Why the study?
What is the incidence and what are the risk factors for amiodarone-induced thyroid dysfunction in adult Japanese patients with congenital heart disease receiving low-dose amiodarone?
Population
131 adult Japanese patients with congenital heart disease (CHD), median age 28 years.
Design
Cohort
Follow-up
median 44 months
Authors
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High AITD incidence despite low-dose amiodarone warrants close thyroid monitoring in adult CHD; leaves optimal screening intervals open for prospective study.
Cohort (n=131)
No
What is the incidence and what are the risk factors for amiodarone-induced thyroid dysfunction in adult Japanese patients with congenital heart disease receiving low-dose amiodarone?
Even at low doses (median 150 mg/day), amiodarone frequently causes thyroid dysfunction (30% incidence) in adult Japanese patients with congenital heart disease.
Takeuchi et al. (2015) conducted a cohort in Congenital heart disease (n=131). Amiodarone vs. None was evaluated on Incidence of amiodarone-induced thyroid dysfunction (AITD). In Japanese adults with congenital heart disease, low-dose amiodarone therapy was associated with a 30% incidence of thyroid dysfunction, and liver dysfunction was an independent risk factor for hypothyroidism (HR 2.573).
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