Key result
Higher plasma brain-derived neurotrophic factor (BDNF) levels were associated with a lower prevalence of frailty (OR 0.353 per 100 pg/mL) and severe sarcopenia in hemodialysis patients.
Why the study?
To identify sarcopenia-related hormones, cytokines, and uremic toxins associated with sarcopenia and frailty in Japanese hemodialysis patients.
Are plasma BDNF levels associated with sarcopenia and frailty in older Japanese hemodialysis patients?
Design
Retrospective cross-sectional study
Authors
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Associations of humoral factors with sarcopenia/frailty in hemodialysis patients are hypothesis-generating; leaves open causal roles and clinical utility.
Cross-Sectional (n=20)
No
Are plasma BDNF levels associated with sarcopenia and frailty in older Japanese hemodialysis patients?
Odds Ratio: 0.353
Lower plasma BDNF levels are associated with decreased physical performance and a higher prevalence of severe sarcopenia and frailty in older Japanese hemodialysis patients.
Miyazaki et al. (2020) conducted a cross-sectional in Sarcopenia and frailty in hemodialysis (n=20). Brain-derived neurotrophic factor (BDNF) was evaluated on Prevalence of frailty (OR 0.353). Higher plasma brain-derived neurotrophic factor (BDNF) levels were associated with a lower prevalence of frailty (OR 0.353 per 100 pg/mL) and severe sarcopenia in hemodialysis patients.
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