Key result
BIS-guided anaesthesia reduced the risk of confirmed awareness by 82% compared to routine care in at-risk adult surgical patients (0.16% vs 0.89%; P=0.022).
Why the study?
Does BIS-guided anesthesia reduce the incidence of awareness during surgery in adult patients at high risk of awareness?
Population
2463 adult surgical patients at high risk of awareness undergoing relaxant general anesthesia
Comparison
Bispectral index (BIS)-guided anesthesia vs Routine care
Design
RCT, randomly allocated, double-blind
Follow-up
30 days
Authors
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BIS-guided anesthesia reduces awareness in high-risk adults; confirms benefit of depth monitoring in this RCT.
RCT (n=2,463)
Double-blind
randomly allocated
Yes
Does BIS-guided anesthesia reduce the incidence of awareness during surgery in adult patients at high risk of awareness?
Effect estimate: 82% risk reduction (95% CI 17-98)
Absolute Event Rate: 0.16% vs 0.89%
Number Needed to Treat: 138
p-value: p=0.022
BIS-guided anesthesia significantly reduces the risk of intraoperative awareness in high-risk surgical patients compared to routine care.
Mędrzycka‐Dąbrowska et al. (2017) conducted an RCT in High risk of awareness during surgery and general anaesthesia (n=2,463). Bispectral index (BIS)-guided anaesthesia vs. Routine care was evaluated on Confirmed awareness under anaesthesia at any time (82% risk reduction, 95% CI 17-98, p=0.022). BIS-guided anaesthesia reduced the risk of confirmed awareness by 82% compared to routine care in at-risk adult surgical patients (0.16% vs 0.89%; P=0.022).
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