Survival after cardiac resynchronization therapy: results from 50 084 implantations
Key result
CRT-D was associated with lower excess mortality compared to CRT-P in patients undergoing cardiac resynchronization therapy (aHR 0.80; 95% CI 0.76-0.84).
Why the study?
Does CRT-D improve relative survival compared to CRT-P in patients undergoing cardiac resynchronization therapy?
Population
50,084 patients undergoing cardiac resynchronization therapy (CRT), mean age 72.1 ± 11.6 years.
Comparison
Cardiac resynchronization therapy with… vs Cardiac resynchronization therapy without…
Design
Cohort
Follow-up
median 2.7 years (IQR 1.3-4.8)
Authors
Discussion
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Member takes
Implication
CRT informs patient expectations versus peers; extends RCT survival data with real-world relative estimates.
Study Design
Type
Cohort (n=50,084)
Multicenter
Yes
Structured PICO
Does CRT-D improve relative survival compared to CRT-P in patients undergoing cardiac resynchronization therapy?
P
Population
50,084 patients with heart failure undergoing cardiac resynchronization therapy with or without defibrillation, followed for a median of 2.7 years.
E
Exposure
Cardiac resynchronization therapy with defibrillation (CRT-D)
C
Comparator
Cardiac resynchronization therapy without defibrillation (CRT-P)
O
Outcome
Observed and relative survival (excess mortality)hard clinical
Main Result
Hazard Ratio: 0.8 (95% CI 0.76–0.84)
Cite This Study
Leyva et al. (2018) conducted a cohort in Heart failure (n=50,084). CRT-D vs. CRT-P was evaluated on excess mortality (aHR 0.80, 95% CI 0.76-0.84). CRT-D was associated with lower excess mortality compared to CRT-P in patients undergoing cardiac resynchronization therapy (aHR 0.80; 95% CI 0.76-0.84).