Key result
Laser speckle flowgraphy detected ocular ischemic syndrome with a sensitivity of 100% and a specificity of 93.8% using the Laterality Index of the entire fundus area.
Why the study?
Can laser speckle flowgraphy (LSFG) detect disparities in fundus blood flow in patients with internal carotid artery occlusion?
Cross-Sectional (n=56)
No
Can laser speckle flowgraphy (LSFG) detect disparities in fundus blood flow in patients with internal carotid artery occlusion?
Laser speckle flowgraphy is a highly sensitive and specific tool for detecting disparities in fundus blood flow associated with internal carotid artery occlusion.
PURPOSE: We investigated whether laser speckle flowgraphy (LSFG) results are comparable in both eyes and whether it is useful in the diagnosis of disparity in ocular ischemic syndrome (OIS) patients. METHODS: We compared the mean blur rate (MBR) value for various fundus regions in both eyes of 41 healthy subjects and 15 internal carotid artery occlusion (ICAO) cases. We calculated the standard value of the Laterality Index (LI), which was the MBR comparison of both eyes in each of the regions, in the control subjects. We then investigated the correlation between both eyes for the LIs in the entire fundus, the degree of ICAO and visual function. RESULTS: The disparity of the LIs in both eyes was least in the entire area of the fundus in control subjects and there was a significant correlation between both eyes of the 41 healthy individuals (P = 0.019). Significant correlations were found for the LI, visual acuity and degree of ICAO. The specificity and sensitivity of LI in the entire area was 93.8% and 100%, respectively. CONCLUSIONS: LSFG revealed normal individuals have symmetrical fundus blood flow. LSFG could detect OIS and might be a useful tool for detecting disparities in fundus blood flow.
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Shinohara et al. (2017) conducted a cross-sectional in Internal Carotid Artery Obstruction (ICAO) / Ocular Ischemic Syndrome (OIS) (n=56). Laser Speckle Flowgraphy (LSFG) vs. Healthy controls was evaluated on Diagnostic accuracy of Laterality Index (LI) in the entire fundus area for Ocular Ischemic Syndrome (100% sensitivity, 93.8% specificity). Laser speckle flowgraphy detected ocular ischemic syndrome with a sensitivity of 100% and a specificity of 93.8% using the Laterality Index of the entire fundus area.
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