Key result
Epicardial adipose tissue thickness was significantly associated with cardiovascular risk predictors including body mass index (β=0.590, P<0.001) and left ventricular mass (β=0.426, P=0.002).
Why the study?
Does echocardiographic epicardial adipose tissue thickness correlate with cardiovascular risk predictors in nondiabetic maintenance hemodialysis patients?
Cross-Sectional (n=50)
Does echocardiographic epicardial adipose tissue thickness correlate with cardiovascular risk predictors in nondiabetic maintenance hemodialysis patients?
Effect estimate: β 0.590 (for body mass index)
p-value: p=<0.001
Echocardiographic epicardial adipose tissue thickness is significantly associated with body fat measures and cardiovascular risk predictors in nondiabetic maintenance hemodialysis patients.
EAT thickness may refine risk assessment in nondiabetic MHD patients; leaves open incremental prognostic value beyond standard predictors.
Epicardial adipose tissue (EAT) is a cardiovascular risk predictor in general population. However, its value has not been well validated in maintainance hemodialysis (MHD) patients. We aimed to assess associations of EAT with cardiovascular risk predictors in nondiabetic MHD patients. In this cross-sectional study, we measured EAT thickness by transthoracic echocardiography in 50 MHD patients (45.8 ± 14.6 years of age, 37 male). Antropometric measurements, bioimpedance analysis, left ventricular (LV) mass, carotis intima media thickness, blood tests, homeostasis model assessment for insulin resistance (HOMA-IR) and hemodialysis dose by single-pool urea clearence index (spKt/V) were determined. The mean EAT thickness was 3.28 ± 1.04 mm. There were significant associations of EAT with body mass index (β = 0.590, P < 0.001), waist circumference (β = 0.572, P < 0.001), body fat mass (β = 0.562, P < 0.001), percentage of body fat mass (β = 0.408, P = 0.003), percentage of lean tissue mass (β = -0.421, P = 0.002), LV mass (β = 0.426, P = 0.002), carotis intima media thickness (β = 0.289, P = 0.042), triglyceride/high-density lipoprotein cholesterol ratio (β = 0.529, P < 0.001), 1/HOMA-IR (β = -0.386, P = 0.006), and spKt/V (β = -0.311, P = 0.028). No association was exhibited with visfatin C, high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha (for all, P > 0.05). Body mass index, waist circumference, body fat mass, percentage of lean tissue mass, LV mass, triglyceride/high-density lipoprotein cholesterol ratio, HOMA-IR, and spKt/V appeared as independent predictors of EAT. EAT was significantly associated with body fat measures, cardiovascular risk predictors, and dialysis dose in MHD patients.
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Okyay et al. (2015) conducted a cross-sectional in Nondiabetic maintenance hemodialysis (n=50). Epicardial adipose tissue (EAT) thickness was evaluated on Associations of EAT with cardiovascular risk predictors (e.g., body mass index, left ventricular mass) (β 0.590 (for body mass index), p=<0.001). Epicardial adipose tissue thickness was significantly associated with cardiovascular risk predictors including body mass index (β=0.590, P<0.001) and left ventricular mass (β=0.426, P=0.002).
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