Key result
Epicardial adipose tissue values were similar between non-diabetic, non-hypertensive hemodialysis patients and healthy controls, despite higher CIMT.
Why the study?
Is epicardial adipose tissue thickness increased in non-diabetic, non-hypertensive hemodialysis patients compared to healthy controls?
Case-Control (n=88)
Is epicardial adipose tissue thickness increased in non-diabetic, non-hypertensive hemodialysis patients compared to healthy controls?
Epicardial adipose tissue thickness is not increased in non-diabetic, non-hypertensive hemodialysis patients, suggesting it may not be a reliable cardiovascular risk indicator in this specific population.
Answers are grounded in this paper and cite their sources.
May not serve as a cardiovascular risk marker in this hemodialysis subgroup; hypothesis-generating for alternative biomarkers beyond diabetes and hypertension.
PURPOSE: It has been found out that the epicardial adipose tissue (EAT) measured by echocardiography is related with various metabolic parameters. Being accepted as the new cardiovascular risk indicator, there have been few studies on EAT in relation to the patients with end-stage renal failure. In our study, we aim to evaluate EAT and carotid intima media thickness (CIMT) in non-diabetic, non-hypertensive hemodialysis (HD) patients. METHODS: Our study recruited 47 non-diabetic, non-hypertensive HD patients (22 males, 25 females, median age 54 (44.3-60.8) years) and an age-gender matched control group consisting 41 healthy subjects (17 males, 24 females, median age 52 (48-56) years). In all patients, EAT was measured by echocardiography and CIMT by ultrasonography; and routine laboratory parameters were studied. RESULTS: In our study, we obtained laboratory findings matching with the profiles of uremic patients among HD patients and CIMT values of HD patients are significantly higher than that of the control group [0.79 (0.64-0.93) vs. 0.6 (0.53-0.68) p < 0.001], and EAT values are similar [0.5 (0.33-0.6) vs. 0.4 (0.4-0.53) p > 0.05]. CONCLUSIONS: EAT is not a cardiovascular risk indicator in HD patients without diabetes mellitus and hypertension. Besides, echocardiographic measurement of EAT is easy, non-invasive, cheap and credible method.
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Özkurt et al. (2013) conducted a case-control in End-stage renal failure on hemodialysis (n=88). Hemodialysis (end-stage renal failure) vs. Healthy subjects was evaluated on Epicardial adipose tissue (EAT) thickness (p=> 0.05). Epicardial adipose tissue values were similar between non-diabetic, non-hypertensive hemodialysis patients and healthy controls, despite higher CIMT.
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