The association between cancer diagnosis, care, and outcomes in 1 million patients hospitalized for acute pulmonary embolism
Key result
Among adults hospitalized for acute pulmonary embolism, a cancer diagnosis was associated with lower odds of invasive management and higher odds of mortality (P<0.05).
Why the study?
To evaluate clinical care provided to cancer patients hospitalized for acute pulmonary embolism, and the association between cancer type, in-hospital care, and clinical outcomes.
Does a concurrent cancer diagnosis affect in-hospital care and clinical outcomes in adults hospitalized for acute pulmonary embolism?
Population
1,090,130 adults hospitalized due to acute PE
Comparison
Patients with current cancer diagnoses vs non-cancer counterparts
Design
Retrospective database study using the National Inpatient Sample (NIS)
Follow-up
In-hospital
Authors
Discussion
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Member takes
Implication
Cancer-associated PE links to less invasive care and higher mortality; leaves open whether disparities reflect appropriate caution or undertreatment.
Study Design
Type
Observational (n=1,090,130)
Multicenter
Yes
Structured PICO
Does a concurrent cancer diagnosis affect in-hospital care and clinical outcomes in adults hospitalized for acute pulmonary embolism?
P
Population
1,090,130 adults hospitalized for acute pulmonary embolism, including 216,825 with a current cancer diagnosis, assessed for in-hospital care and clinical outcomes.
E
Exposure
Current cancer diagnosis (including lung, hematological, colorectal, breast, prostate, and other cancers)
C
Comparator
No current cancer diagnosis
O
Outcome
In-hospital care (systemic thrombolysis, catheter-directed thrombolysis, and surgical thrombectomy/embolectomy) and clinical outcomes (mortality, major bleeding, and hemorrhagic stroke)hard clinical
Main Result
Odds Ratio: 2.68 (95% CI 2.61–2.76)
p-value: p=<0.001
In patients hospitalized for acute pulmonary embolism, a concurrent cancer diagnosis is associated with less frequent use of invasive management and higher rates of in-hospital mortality and bleeding.
Limitations
- Appropriateness of care could not be assessed in this study.
Cite This Study
Shengting et al. (2022) conducted an observational in Acute pulmonary embolism (n=1,090,130). Cancer diagnosis vs. No cancer diagnosis was evaluated on In-hospital mortality (lung cancer vs non-cancer) (aOR 2.68, 95% CI 2.61-2.76, p=<0.001). Among adults hospitalized for acute pulmonary embolism, a cancer diagnosis was associated with lower odds of invasive management and higher odds of mortality (P<0.05).