Key result
Mangiferin attenuates TMAO-induced atherosclerosis in mice via anti-inflammatory, lipid-lowering, and gut-microbiota modulation.
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. This modulation led to a decrease in plasma lipopolysaccharide levels, enhanced the production of total SCFAs by gut microbes, and reduced susceptibility to atherosclerosis. In conclusion, mangiferin exhibited its ability to alleviate TMAO-induced atherosclerosis through its anti-inflammatory, cholesterol-lowering, and gut microbial modulatory activities.
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He et al. (2023) studied this question. Mangiferin alleviated TMAO-induced atherosclerosis in mice through anti-inflammatory, cholesterol-lowering, and gut microbial modulatory activities.
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