Key result
Compared to the SAPIEN XT, the SAPIEN 3 prosthesis significantly reduced the incidence of more-than-mild post-TAVI aortic regurgitation (2.0% vs. 8.8%, p<0.01).
Why the study?
Does the third-generation S3 balloon-expandable prosthesis reduce post-TAVI aortic regurgitation compared to the second-generation SXT prosthesis in patients with symptomatic aortic stenosis?
Cohort (n=454)
No
Does the third-generation S3 balloon-expandable prosthesis reduce post-TAVI aortic regurgitation compared to the second-generation SXT prosthesis in patients with symptomatic aortic stenosis?
Odds Ratio: 0.54 (95% CI 0.33–0.89)
Absolute Event Rate: 2% vs 8.8%
p-value: p=<0.01
The third-generation S3 balloon-expandable prosthesis significantly reduces post-TAVI aortic regurgitation compared to the second-generation SXT, though it is associated with a higher rate of new left bundle branch block.
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S3 use linked to lower >mild AR than SXT; observational data leaves open clinical impact and need for randomized trials.
Jochheim et al. (2015) conducted a cohort in Symptomatic aortic stenosis (n=454). SAPIEN 3 prosthesis vs. SAPIEN XT prosthesis was evaluated on More-than-mild post-TAVI aortic regurgitation at discharge (OR 0.54, 95% CI 0.33-0.89, p=<0.01). Compared to the SAPIEN XT, the SAPIEN 3 prosthesis significantly reduced the incidence of more-than-mild post-TAVI aortic regurgitation (2.0% vs. 8.8%, p<0.01).
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