Key result
Respiratory center activity induces rhythmic fluctuations in heart rate and ventricular contractility in canine left ventricles, mediated predominantly via the vagi and sympathetic influences.
Population
innervated, isovolumetric, canine, left ventricle preparations
Comparison
Bilateral vagotomy and cardiac pacing vs Baseline state
Design
Preclinical
Authors
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Central vagal mediation of respiratory HR/contractility waves in dogs; leaves open human autonomic translation.
This preclinical study elucidates the distinct autonomic pathways mediating respiratory-induced fluctuations in heart rate and ventricular contractility.
Levy et al. (1966) studied this question. Respiratory center activity was evaluated on Heart rate and ventricular contractility fluctuations. Respiratory center activity induces rhythmic fluctuations in heart rate and ventricular contractility in canine left ventricles, mediated predominantly via the vagi and sympathetic influences.
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