Population
Dogs weighing 20-30 kg anaesthetized with chloralose, undergoing closed-chest cardiopulmonary bypass
Comparison
Complete muscular paralysis with gallamine… vs Baseline state (pre-paralysis, pre-vagotomy)
Design
Preclinical
Authors
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No immediate implications for clinical ventilatory management; confirms Breuer's hypothesis of independent inspiratory-expiratory control in animal models.
The study confirms Breuer's hypothesis, demonstrating that the vagus nerves exert tonic control over respiratory rhythm and that inspiratory and expiratory durations are controlled independently.
Bartoli et al. (1973) studied this question.
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