Key result
Reverse-dipping (<0% nighttime BP fall) was associated with an increased risk of cardiovascular events compared to normal dipping (HR 2.29; 95% CI 1.31-3.99).
Why the study?
Does the specific percentage of nighttime blood pressure fall predict cardiovascular events in hypertensive patients?
Population
1200 hypertensive patients (645 women, age 51+/-12 years) under stabilized therapy
Comparison
Subdivisions of nighttime blood pressure fall… vs Dippers (nighttime blood pressure fall 10%-19.9%)
Design
Cohort
Follow-up
8.2 years (title) / up to 15.2 years (abstract)
Authors
Loading...
May refine nocturnal BP risk stratification in hypertension; leaves open whether targeting specific dipping ranges improves outcomes.
Cohort (n=1,200)
Does the specific percentage of nighttime blood pressure fall predict cardiovascular events in hypertensive patients?
Hazard Ratio: 2.29 (95% CI 1.31–3.99)
Nondipping nighttime blood pressure is associated with higher cardiovascular risk only when the BP fall is <5%, suggesting current nondipping classifications may need redefinition.
Bastos et al. (2010) conducted a cohort in Hypertension (n=1,200). Nighttime blood pressure fall <0% (reverse-dippers) vs. Nighttime blood pressure fall 10%-19.9% (dippers) was evaluated on Cardiovascular fatal/nonfatal events (HR 2.29, 95% CI 1.31-3.99). Reverse-dipping (<0% nighttime BP fall) was associated with an increased risk of cardiovascular events compared to normal dipping (HR 2.29; 95% CI 1.31-3.99).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: