What question did this study set out to answer?

To investigate how age impacts extubation time and propofol dosage requirements during medium-duration surgeries in children.

July 21, 2026Scientific ReportsOpen Access

Age-related differences in extubation time following propofol-based target-controlled infusion in pediatric medium-duration surgery: A prospective cohort study

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Prospective cohort study assesses extubation time in pediatric surgery patients, indicating aging affects propofol dosage but not extubation timing.

To investigate how age impacts extubation time and propofol dosage requirements during medium-duration surgeries in children.
Prospective cohort study conducted in a tertiary university hospital from August 2022 to June 2023.
Involved 47 children aged 12 months to 15 years undergoing elective surgery lasting ≥ 120 min using propofol TCI.
Participants were divided into four age groups: 12-23 months, 2-6 years, 7-11 years, and 12-15 years.
No significant differences in extubation time among age groups (mean 12.1-17.8 min; ANOVA p > 0.05).
Propofol requirements decreased significantly with age (Spearman's r = -0.80, p < 0.0001).
No predictive relationship between age or propofol dose and extubation time (R² = 0.052, p = 0.314).

Jindawatthana et al. (2026) studied this question.

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Prospective cohort study assesses extubation time in pediatric surgery patients, indicating aging affects propofol dosage but not extubation timing.