Key result
Pseudo-unipolar mapping identifies isolated pulmonary veins with ~97% accuracy, outperforming bipolar mapping.
Why the study?
To evaluate the electro-anatomic mapping capabilities, acquisition modes, and near- and far-field signal effects of a pulsed field ablation catheter system previously guided by fluoroscopy.
Does pseudo-unipolar mapping mode improve the accuracy of assessing acute pulmonary vein isolation compared to bipolar mapping mode in patients undergoing pulsed field ablation for paroxysmal atrial fibrillation?
Observational (n=15)
Blinded assessors
No
Does pseudo-unipolar mapping mode improve the accuracy of assessing acute pulmonary vein isolation compared to bipolar mapping mode in patients undergoing pulsed field ablation for paroxysmal atrial fibrillation?
Pseudo-unipolar mapping significantly improves the accuracy of assessing pulmonary vein isolation post-pulsed field ablation compared to standard bipolar mapping.
Answers are grounded in this paper and cite their sources.
Pseudo-unipolar mapping may improve pulmonary vein isolation assessment after pulsed field ablation; hypothesis-generating and requires prospective validation before practice change.
BACKGROUND: We assessed the electro-anatomic mapping (EAM) capabilities of a pulsed field ablation (PFA) system previously guided by fluoroscopy to assess acquisition modes, and effects of near and far-field signal. METHODS: After pulmonary vein isolation (PVI) proven by pacing to check entrance and exit block, EAM was performed in 2 modes with the Faraview system during CS pacing. Mode 1 utilized bipoles between electrode 3 of each adjacent catheter spline. Mode 2 utilized a pseudo-unipole between electrode 3 and a combination of electrodes 1, 2, and 4 on individual splines. Signals and voltage map demonstration of PVI were compared with pacing assessment. Two observers assessed the maps with a third observer to resolve discrepancies. RESULTS: Fifteen patients (87% male, aged 58 ± 9 years) had PVI then mapping with the Faraview system. Pacing confirmed isolation of all pulmonary veins. Bipolar mapping (mode 1) displayed multiple apparent PV signals: only 32/61 (52%) of veins appeared isolated. On pseudo-unipolar mapping 59/61 (97%) of veins appeared isolated. The majority of variance in assessment (70.4%) was explainable by the mapping method with minimal variance attributed to observer. CONCLUSIONS: Pseudo-unipolar EAM Faraview mode appears the most accurate for assessment post-PVI compared with bipolar mode.
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Fitzgerald et al. (2026) conducted an observational in Paroxysmal Atrial Fibrillation (n=15). Pseudo-unipolar mapping mode (Faraview system) vs. Bipolar mapping mode was evaluated on Proportion of pulmonary veins appearing isolated on mapping compared to pacing confirmation. Pseudo-unipolar mapping mode accurately identified 97% of isolated pulmonary veins compared to only 52% with bipolar mapping mode.
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