Key result
Aging in rats was associated with an impaired endothelium-dependent hypotensive response, enhanced expression of eNOS and iNOS isoforms, but reduced eNOS activity in the vessel wall.
Aging in rats is associated with reduced eNOS activity despite increased eNOS and iNOS expression, explaining the impaired endothelium-dependent hypotensive response.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating for age-related eNOS uncoupling; leaves open translation to human endothelial therapies.
Cernadas et al. (1998) studied Aging (n=40). Aging vs. Young rats (5 months old) was evaluated on Hypotensive response to acetylcholine, bradykinin, and sodium nitroprusside, and expression/activity of NOS isoforms. Aging in rats was associated with an impaired endothelium-dependent hypotensive response, enhanced expression of eNOS and iNOS isoforms, but reduced eNOS activity in the vessel wall.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: