Key result
Repair of coarctation of the aorta in paediatric patients resulted in persistent left ventricular hypertrophy and larger left ventricular size compared to controls at 12 months follow-up.
Why the study?
Does successful repair of coarctation of the aorta normalize left ventricular size and function in paediatric patients compared to controls?
Observational (n=30)
Does successful repair of coarctation of the aorta normalize left ventricular size and function in paediatric patients compared to controls?
Left ventricular hypertrophy and enlargement persist one year after successful coarctation repair in pediatric patients, indicating ongoing cardiovascular remodeling despite treatment.
LV remodeling warrants serial monitoring after pediatric CoA repair; leaves open optimal 3D echo thresholds and long-term outcomes.
OBJECTIVES: To evaluate cardiac size and function in patients with coarctation of the aorta (CoA) before and after treatment. DESIGN: Ventricular size and function were examined by 2- and 3-dimensional echocardiography, and concentrations of natriuretic peptides measured in 15 paediatric patients before repair, and one, 6, and 12 months thereafter. Controls comprised 15 children. RESULTS: Before repair, mitral inflow velocities and left ventricular (LV) size and wall thickness were higher in patients. Thicknesses of interventricular septum and LV posterior wall decreased after repair but increased to initial level one year thereafter. The LV end-diastolic diameter remained larger than in controls despite successful repair. The size of right ventricle increased and levels of natriuretic peptides decreased during follow-up. Levels of natriuretic peptides correlated with the smallest diameter of CoA segment and diastolic indices of LV function. CONCLUSION: LV hypertrophy persists and LV size remains larger than in controls after successful repair even in normotensive patients with normal growth of CoA segment. This may be due to remodelling of ventricles and the aorta caused by CoA.
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Eerola et al. (2007) conducted an observational in Coarctation of the aorta (n=30). Repair of coarctation of the aorta vs. Healthy controls was evaluated on Cardiac size and function (left ventricular hypertrophy and size). Repair of coarctation of the aorta in paediatric patients resulted in persistent left ventricular hypertrophy and larger left ventricular size compared to controls at 12 months follow-up.
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