Key result
Various therapeutic options including oral anticoagulation, heparin, fresh frozen plasma, and protein C concentrate are used for the long-term management of severe protein C deficiency.
Why the study?
What are the therapeutic options for the clinical management of protein C deficiency?
Population
Patients with acquired or hereditary (heterozygous, homozygous, or doubly heterozygous) protein C deficiency
Design
Review
Authors
Loading...
Multiple options guide severe protein C deficiency management; leaves open comparative trials for optimal long-term regimens.
What are the therapeutic options for the clinical management of protein C deficiency?
Standard therapy for heterozygous protein C deficiency involves coumarin derivatives or heparin, while homozygous cases may require FFP, IV protein C concentrate, or coumarin derivatives to normalize hemostasis and resolve symptoms.
S Pescatore (2001) conducted a review in Protein C deficiency. Therapeutic options (oral anticoagulation, heparin, FFP, PC concentrate, LMWH, steroids, liver transplantation) was evaluated. Various therapeutic options including oral anticoagulation, heparin, fresh frozen plasma, and protein C concentrate are used for the long-term management of severe protein C deficiency.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: