Key result
Review of 11 pediatric observational studies and 6 adult RCTs indicates regional citrate anticoagulation decreases bleeding and provides equivalent circuit survival compared to heparin.
Why the study?
Does regional citrate anticoagulation reduce bleeding and maintain circuit survival compared to systemic heparin in pediatric critical care patients requiring continuous renal replacement therapy?
Population
Pediatric critical care patients requiring continuous renal replacement therapy
Comparison
Regional citrate anticoagulation vs Systemic heparin anticoagulation
Design
Review
Authors
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Supports consideration of regional citrate for bleeding reduction in pediatric CRRT; leaves open need for pediatric RCTs to confirm equivalence.
Does regional citrate anticoagulation reduce bleeding and maintain circuit survival compared to systemic heparin in pediatric critical care patients requiring continuous renal replacement therapy?
Regional citrate anticoagulation is an effective and safe alternative to systemic heparin for continuous renal replacement therapy in critically ill children, offering decreased bleeding risk and equivalent circuit survival.
Davis et al. (2014) conducted a review in Pediatric critical care requiring continuous renal replacement therapy. Regional citrate anticoagulation vs. Systemic heparin anticoagulation was evaluated. Review of 11 pediatric observational studies and 6 adult RCTs indicates regional citrate anticoagulation decreases bleeding and provides equivalent circuit survival compared to heparin.
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