Why the study?
Does regional citrate anticoagulation improve filter life compared to standard heparin anticoagulation in patients undergoing continuous renal replacement therapy?
Does regional citrate anticoagulation improve filter life compared to standard heparin anticoagulation in patients undergoing continuous renal replacement therapy?
Regional citrate anticoagulation significantly prolongs filter life and reduces costs compared to standard heparin in CRRT, though metabolic alkalosis and hypercalcemia require monitoring.
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Citrate anticoagulation was associated with longer filter life in this cohort; leaves open whether it improves CRRT outcomes versus heparin in randomized trials.
Morgera et al. (2004) studied this question.
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