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August 31, 2020Catheterization and Cardiovascular Interventions

Percutaneous thrombectomy in patients with massive and very high‐risk submassive acute pulmonary embolism

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Why the study?

The FlowTriever thrombectomy system reduces right ventricle strain in acute submassive pulmonary embolism, but had not been studied in higher-risk pulmonary embolism patients.

Does percutaneous aspiration thrombectomy improve hemodynamics and clinical outcomes in patients with massive and very high-risk submassive acute pulmonary embolism?

Population

34 high-risk acute PE patients with vasopressor dependence, respiratory failure, or decreased cardiac index

Comparison

FlowTriever percutaneous thrombectomy

Design

Multicenter retrospective analysis

Follow-up

Mean 205 days

Key result

FlowTriever aspiration thrombectomy in high-risk acute pulmonary embolism patients achieved successful clot removal in 94.1% of patients and significantly improved cardiac index (p=0.01).

Authors

CTCatalin TomaSKSameer KhandharAZAdrian Zalewski

Discussion

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Member takes

Overview

FlowTriever thrombectomy appears feasible in high-risk PE; hypothesis-generating and requires prospective trials before clinical adoption.

Study Design

Type

Observational (n=34)

Multicenter

Yes

Structured PICO

Does percutaneous aspiration thrombectomy improve hemodynamics and clinical outcomes in patients with massive and very high-risk submassive acute pulmonary embolism?

P
Population
34 patients with massive or high-risk submassive acute pulmonary embolism treated with FlowTriever, followed for a mean of 205 days.
E
Exposure
Percutaneous aspiration thrombectomy (FlowTriever system)
O
Outcome
Feasibility, hemodynamic improvement (cardiac index, mean pulmonary artery pressure), and in-hospital mortalitysurrogate

Cite This Study

Toma et al. (2020) conducted an observational in massive and very high-risk submassive acute pulmonary embolism (n=34). FlowTriever thrombectomy was evaluated on Clot removal success. FlowTriever aspiration thrombectomy in high-risk acute pulmonary embolism patients achieved successful clot removal in 94.1% of patients and significantly improved cardiac index (p=0.01).

synapsesocial.com/papers/6a5f58a4278d7ef6147dff7bhttps://doi.org/10.1002/ccd.29246
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Prospective, Single-Arm, Multicenter Trial of Catheter-Directed Mechanical Thrombectomy for Intermediate-Risk Acute Pulmonary Embolism2019 · 560 citations
  2. 2Pulmonary Embolism With Syncope Treated With Inari FlowTriever®2024
  3. 3Outcomes in high-risk pulmonary embolism patients undergoing FlowTriever mechanical thrombectomy: the FLAME study in perspective2023 · 14 citations
  4. 4FlowTriever System for Pulmonary Embolism: A Review of Clinical Evidence2023
  5. 5Longer-Term Outcomes Following Mechanical Thrombectomy for Intermediate- and High-Risk Pulmonary Embolism: 6-Month FLASH Registry Results2023 · 19 citations