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May 1, 2019КАРДИОЛОГИЯ УЗБЕКИСТАНАOpen Access

A Prospective, Single-Arm, Multicenter Trial of Catheter-Directed Mechanical Thrombectomy for Intermediate-Risk Acute Pulmonary Embolism

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Why the study?

Catheter-directed thrombolysis improves RV function in PE but increases bleeding risk, and many patients have contraindications to thrombolysis.

Does percutaneous mechanical thrombectomy improve RV/LV ratio in patients with acute intermediate-risk pulmonary embolism?

Population

106 patients with acute intermediate-risk PE and RV/LV ratios ≥0.9

Comparison

Percutaneous mechanical thrombectomy using the FlowTriever System (single-arm)

Design

Prospective, single-arm, multicenter trial

Follow-up

30 days

Authors

TTThomas TuCTCatalin TomaVTVictor F. Tapson

Discussion

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Member takes

Overview

May support FlowTriever use in intermediate-risk PE; leaves open need for randomized comparisons versus thrombolysis.

Structured PICO

Does percutaneous mechanical thrombectomy improve RV/LV ratio in patients with acute intermediate-risk pulmonary embolism?

P
Population
n=106 patients with symptomatic, computed tomography-documented acute intermediate-risk pulmonary embolism (PE) and RV/LV ratios ≥0.9, treated at 18 U.S. sites.
I
Intervention
Percutaneous mechanical thrombectomy using the FlowTriever System
O
Outcome
Core laboratory-assessed change in RV/LV ratio at 48 hours post-procedure (effectiveness) and composite of device-related death, major bleeding, treatment-related clinical deterioration, pulmonary vascular injury, or cardiac injury within 48 h of thrombectomy (safety)surrogate

Percutaneous mechanical thrombectomy significantly improves RV/LV ratio with minimal major bleeding in patients with acute intermediate-risk pulmonary embolism, offering a potential alternative to thrombolysis.

Cite This Study

Tu et al. (2019) studied this question.

synapsesocial.com/papers/6a7cfa64c502fdf5e03945fbhttps://doi.org/10.1016/j.jcin.2018.12.022
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Percutaneous thrombectomy in patients with massive and very <scp>high‐risk</scp> submassive acute pulmonary embolism2020 · 50 citations
  2. 2Longer-Term Outcomes Following Mechanical Thrombectomy for Intermediate- and High-Risk Pulmonary Embolism: 6-Month FLASH Registry Results2023 · 19 citations
  3. 3Outcomes in high-risk pulmonary embolism patients undergoing FlowTriever mechanical thrombectomy: the FLAME study in perspective2023 · 14 citations
  4. 4FlowTriever System for Pulmonary Embolism: A Review of Clinical Evidence2023
  5. 5Mechanical thrombectomy in intermediate- and high-risk acute pulmonary embolism: hemodynamic outcomes at three months2023 · 28 citations