Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
August 28, 2026Acta cardiologica. Supplementum

First Belgian experience with large-bore mechanical thrombectomy in acute pulmonary embolism using the FlowTriever ® system: a bi-centre retrospective analysis

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Large-bore mechanical thrombectomy is an emerging treatment for high-risk and intermediate-high-risk PE, especially in patients with contraindications to thrombolysis, but safety and clinical outcomes warranted evaluation in this setting.

Does large-bore mechanical thrombectomy improve hemodynamics and clinical outcomes in patients with acute pulmonary embolism?

Comparison

Large-bore mechanical thrombectomy using the FlowTriever system (single-arm)

Design

Bi-centre retrospective cohort study

Follow-up

30 days

Key result

Large-bore mechanical thrombectomy using the FlowTriever system decreased mean pulmonary artery pressure by 27% (p<0.0001) with a 5% rate of major complications and 5% 30-day mortality.

Authors

SSSébastien SelleslagJMJesse MarrannesLBLawrence Bonne

Discussion

Loading...

Member takes

Overview

LBMT with FlowTriever appears feasible in acute PE; leaves open comparative efficacy versus thrombolysis or anticoagulation in randomized trials.

Key Points

  • To assess the safety, technical success, and clinical outcomes of large-bore mechanical thrombectomy using the FlowTriever system in patients with acute pulmonary embolism.
  • Retrospectively analyzed N=60 patients (mean age 61.9 ± 13.9 years) with intermediate-high-risk (81.7%) and high-risk (13.3%) acute pulmonary embolism treated between February 2022 and November 2024 across two Belgian centers.
  • Evaluated primary endpoints of mean pulmonary artery pressure (mPAP) reduction, major procedural complications, and 30-day mortality alongside hospital metrics.
  • Technical success reached 96.7%, and mean pulmonary artery pressure decreased by 27% (p < 0.0001).
  • Major complications occurred in 5.0% of patients (two pulmonary artery perforations in acute-on-chronic cases and one intraoperative cardiac arrest), with 0% major bleeding.
  • Thirty-day mortality was 5.0%, survival to discharge was 93.3%, and elevated baseline lactate was significantly linked to adverse outcomes (p = 0.009).

Study Design

Type

Cohort (n=60)

Multicenter

Yes

Structured PICO

Does large-bore mechanical thrombectomy improve hemodynamics and clinical outcomes in patients with acute pulmonary embolism?

P
Population
60 patients (mean age 61.9 years, 48.3% female) with acute pulmonary embolism (81.7% intermediate-high-risk, 13.3% high-risk) treated with the FlowTriever system, followed for 30 days.
E
Exposure
Large-bore mechanical thrombectomy (LBMT) using the FlowTriever system
O
Outcome
Reduction in mean pulmonary artery pressure (mPAP), major procedural complications, and 30-day mortality

Main Result

p-value: p=<0.0001

Large-bore mechanical thrombectomy with the FlowTriever system provides rapid hemodynamic improvement and high technical success in selected patients with acute pulmonary embolism.

Limitations

  • Retrospective design
  • Lack of prospective comparative data
  • Unclear long-term benefit

Cite This Study

Selleslag et al. (2026) conducted a cohort in acute pulmonary embolism (n=60). Large-bore mechanical thrombectomy (FlowTriever) was evaluated on reduction in mean pulmonary artery pressure (mPAP) (p=<0.0001). Large-bore mechanical thrombectomy using the FlowTriever system decreased mean pulmonary artery pressure by 27% (p<0.0001) with a 5% rate of major complications and 5% 30-day mortality.

synapsesocial.com/papers/6a914622d15324a1df3a9837https://doi.org/10.1080/00015385.2026.2698745
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Randomized Controlled Trial of Mechanical Thrombectomy With Anticoagulation Versus Anticoagulation Alone for Acute Intermediate-High Risk Pulmonary Embolism: Primary Outcomes From the STORM-PE Trial2025 · 64 citations
  2. 2Evaluation of Naples prognostic score to predict long-term mortality in patients with pulmonary embolism2024 · 24 citations
  3. 3A Prospective, Single-Arm, Multicenter Trial of Catheter-Directed Mechanical Thrombectomy for Intermediate-Risk Acute Pulmonary Embolism2019 · 561 citations
  4. 4Multimodality imaging of acute and chronic pulmonary thromboembolic disease2024 · 7 citations
  5. 5From thrombosis to fibrosis in chronic thromboembolic pulmonary hypertension2017 · 93 citations