Why the study?
Mechanical thrombectomy provides rapid hemodynamic improvements after acute pulmonary embolism, but long-term benefits remain uncertain.
Does mechanical thrombectomy improve long-term symptoms, right ventricular function, and quality of life in patients with acute pulmonary embolism?
Population
799 patients with acute PE treated with the FlowTriever System
Design
Prospective, single-arm, multicenter registry
Follow-up
Mean 204 ± 46 days
Key result
Mechanical thrombectomy with the FlowTriever system for acute pulmonary embolism was associated with 4.6% 6-month mortality and improved normal RV function from 15.1% to 95.1% (P<0.0001).
Authors
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Sustained 6-month gains in symptoms, RV function, and exercise capacity support thrombectomy durability in PE; leaves open randomized confirmation of long-term benefit.
Cohort (n=799)
Yes
Does mechanical thrombectomy improve long-term symptoms, right ventricular function, and quality of life in patients with acute pulmonary embolism?
Absolute Event Rate: 95.1% vs 15.1%
p-value: p=<.0001
Mechanical thrombectomy for acute pulmonary embolism is associated with low 6-month mortality and significant improvements in right ventricular function, symptoms, and quality of life.
Khandhar et al. (2023) conducted a cohort in Acute pulmonary embolism (n=799). Mechanical thrombectomy (FlowTriever System) vs. Baseline was evaluated on Normal echocardiographic right ventricular (RV) function at 6 months compared to baseline (p=<.0001). Mechanical thrombectomy with the FlowTriever system for acute pulmonary embolism was associated with 4.6% 6-month mortality and improved normal RV function from 15.1% to 95.1% (P<0.0001).