Key result
The HVCN1 proton channel mediates pH-regulated acid secretion in airway epithelia, and the naturally occurring M91T mutation requires approximately 0.5 pH units more alkaline mucosal pH for activation.
Population
JME airway epithelia cells, primary human airway epithelia, and 95 human genomic DNA samples
Comparison
siRNA-mediated knockdown of HVCN1 mRNA… vs Wild-type HVCN1 epithelia
Design
Preclinical
Authors
Loading...
M91T HVCN1 may alter airway acid secretion thresholds in models; extends HVCN1 data but leaves open human relevance.
The HVCN1 proton channel mediates pH-regulated acid secretion in airway epithelium, and the naturally occurring M91T mutation alters its pH sensitivity.
Iovannisci et al. (2010) studied Airway epithelia function (n=95). M91T HVCN1 mutation vs. Wild-type HVCN1 was evaluated on pH-dependent acid secretion and H(+) currents. The HVCN1 proton channel mediates pH-regulated acid secretion in airway epithelia, and the naturally occurring M91T mutation requires approximately 0.5 pH units more alkaline mucosal pH for activation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: