Key result
The generic 15D instrument showed moderately strong correlations with dyspnea and physical limitation measures but correlated poorly with angina frequency measured by the SAQ-7 in CAD patients.
Why the study?
It was unknown how well the generic 15D instrument captures disease-specific information compared to instruments in the ICHOM standard set for CAD patients.
Does the generic 15D HRQoL instrument capture disease-related symptoms similarly to disease-specific ICHOM instruments in CAD patients?
Observational (n=279)
No
Does the generic 15D HRQoL instrument capture disease-related symptoms similarly to disease-specific ICHOM instruments in CAD patients?
The generic 15D HRQoL instrument may need to be supplemented with disease-specific instruments like the SAQ-7 to adequately capture angina symptoms in CAD patients.
Answers are grounded in this paper and cite their sources.
15D performance for disease-specific cardiac PROs remains unproven; leaves open optimal instrument selection.
BACKGROUND: Patient-reported outcome (PRO) instruments measure health gains, including changes in health-related quality of life (HRQoL). Previous studies have assessed the reliability and relationship of multiple HRQoL instruments in search of the optimal instrument for feasible measurement of PROs. Although the 15D instrument was shown to have the best sensitivity and construct validity among cardiac patients, it is unknown how well it captures relevant disease-specific information scores compared to instruments included in the International Consortium for Health Outcomes Measurement (ICHOM) standard set. The aim of this study was to investigate whether the disease-specific PRO instruments and a generic HRQoL instrument capture disease related symptoms in coronary artery disease (CAD) patients. METHODS: Health status and HRQoL were assessed with the instruments included in the ICHOM standard set: Seattle Angina Questionnaire short-form (SAQ-7), Rose Dyspnea Scale (RDS), two-item Patient Health Questionnaire (PHQ-2), and with the 15D HRQoL instrument at baseline and 1 year from the treatment in a university hospital setting. Spearman correlation and explanatory factor analysis were used to assess the relationship of baseline scores and 1-year change in scores of 297 patients. RESULTS: At baseline, the overall 15D score and SAQ-physical limitation (SAQ-PL), 15D "breathing" and SAQ-PL, as well as "breathing" and RDS showed moderately strong correlations. The factor interpreted to reflect "Breathing-related physical activity", based on high loadings of "breathing", RDS, SAQ-PL, "mobility", "vitality", and "usual activities", explained 19.2% of the total variance. Correlations between 1-year changes in scores were fair. The factor of "Breathing-related physical activity", with significant loading of RDS, SAQ-PL, "breathing, "usual activities", "vitality", "sexual activity", "mobility", and disease-specific quality of life explained 20.5% of the total variance in 1-year change in scores. The correlation of angina frequency measured by SAQ-7 and the 15D instrument was poor. CONCLUSIONS: The 15D detects dyspnea and depression similarly to RDS and PHQ-2 but not angina similarly to the SAQ-7. This may call for supplementing the 15D instrument with a disease-specific instrument when studying CAD patients.
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Lappalainen et al. (2021) conducted an observational in Coronary artery disease (n=279). 15D generic HRQoL instrument vs. ICHOM standard set (SAQ-7, RDS, PHQ-2) was evaluated on Correlation between 15D and ICHOM standard set instruments. The generic 15D instrument showed moderately strong correlations with dyspnea and physical limitation measures but correlated poorly with angina frequency measured by the SAQ-7 in CAD patients.
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