Key result
Albuminuria, even within the normal range, was associated with greater left ventricular wall thickness (P=0.01), worse diastolic function (P=0.01), and greater arterial stiffness (P<0.0001).
Why the study?
Is renal impairment (albuminuria or reduced eGFR) associated with adverse cardiac structure and diastolic dysfunction in asymptomatic hypertensive patients?
Cross-Sectional (n=540)
Is renal impairment (albuminuria or reduced eGFR) associated with adverse cardiac structure and diastolic dysfunction in asymptomatic hypertensive patients?
p-value: p=0.01
In asymptomatic hypertensive patients with diastolic dysfunction, albuminuria (even within the normal range) is associated with adverse cardiac remodeling and worse diastolic function, whereas eGFR is not.
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Suggests renal markers may help identify asymptomatic hypertensive patients at risk for diastolic dysfunction.
Shah et al. (2011) conducted a cross-sectional in chronic hypertension and diastolic dysfunction (n=540). Albuminuria and reduced estimated glomerular filtration rate (eGFR) vs. Undetectable/normal albuminuria and normal eGFR was evaluated on Left ventricular structure, function, and ventricular-arterial interaction (p=0.01). Albuminuria, even within the normal range, was associated with greater left ventricular wall thickness (P=0.01), worse diastolic function (P=0.01), and greater arterial stiffness (P<0.0001).
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