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February 17, 2016European Journal of Preventive CardiologyOpen Access

High-sensitivity cardiac troponin T is associated with cognitive decline in older adults at high cardiovascular risk

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Key result

Higher levels of high-sensitivity cardiac troponin T were associated with worse cognitive function and steeper cognitive decline in older adults, independent of cardiovascular diseases, risk factors, and NT-proBNP.

Why the study?

Are higher levels of hs-cTnT associated with worse cognitive function and steeper cognitive decline in older adults at high cardiovascular risk?

Population

5,407 older adults with pre-existing cardiovascular disease or elevated risk factors from the PROSPER trial…

Comparison

Higher levels of high-sensitivity cardiac… vs Lower levels of high-sensitivity cardiac…

Design

Cohort

Follow-up

mean 3.2 years

Authors

LWLiselotte W. WijsmanGeneral / Preventive / LipidsACAnton JM de CraenLeiden UniversitySTStella TrompetPreventive Cardiology

Discussion

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Implication

May warrant cognitive monitoring in older high-risk adults with elevated hs-cTnT; extends biomarker utility to longitudinal brain outcomes in RCT cohorts.

Study Design

Type

Cohort (n=5,407)

Multicenter

Yes

Structured PICO

Are higher levels of hs-cTnT associated with worse cognitive function and steeper cognitive decline in older adults at high cardiovascular risk?

P
Population
5,407 older adults (aged 70-82 years) with pre-existing cardiovascular disease or risk factors, free of advanced clinical heart failure, followed for a mean of 3.2 years.
E
Exposure
Higher levels of high-sensitivity cardiac troponin T (hs-cTnT) measured at 6 months (highest third: 0.010-1.840 mg/l)
C
Comparator
Lower levels of high-sensitivity cardiac troponin T (lowest third: 0.002-0.004 mg/l)
O
Outcome
Cognitive function and cognitive decline measured by Stroop test, Letter-Digit Coding test, and immediate/delayed Picture-Word Learning tests over a mean follow-up of 3.2 yearssurrogate

Main Result

Absolute Event Rate: 1.06% vs 0.34%

p-value: p=0.013

Elevated high-sensitivity cardiac troponin T is an independent predictor of cognitive decline in older adults with high cardiovascular risk, suggesting a link between subclinical myocardial injury and cognitive impairment.

Limitations

  • All participants had cardiovascular diseases or risk factors, which might restrict extrapolation to a general population.
  • Potential residual confounding despite adjustment for known risk factors.
  • Lack of extensive information on cardiac functioning, such as echocardiography data.

Cite This Study

Wijsman et al. (2016) conducted a cohort in Cardiovascular disease or risk factors (n=5,407). High-sensitivity cardiac troponin T (hs-cTnT) vs. Lowest third of hs-cTnT was evaluated on Annual change in Stroop test score (seconds) (p=0.013). Higher levels of high-sensitivity cardiac troponin T were associated with worse cognitive function and steeper cognitive decline in older adults, independent of cardiovascular diseases, risk factors, and NT-proBNP.

synapsesocial.com/papers/6a5f84a343fbe6fe485ff084https://doi.org/10.1177/2047487316632364

Topics

Women and heart diseaseStatin therapyCardiovascular prevention
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Also Consider

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  1. 1High-sensitivity cardiac troponin T and cognitive function and dementia risk: the atherosclerosis risk in communities study2014 · 61 citations
  2. 2Testing cognitive function in elderly populations: the PROSPER study2002 · 155 citations
  3. 3Left ventricular dysfunction: a clue to cognitive impairment in older patients with heart failure1997 · 256 citations
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