Key result
Higher baseline hs-cTnT levels in elderly inpatients with non-acute coronary syndrome were associated with an increased risk of all-cause death (adjusted HR 3.01; 95% CI 1.67-5.43; P<0.001).
Why the study?
Does elevated hs-cTnT predict all-cause death in elderly inpatients with non-acute coronary syndrome?
Cohort (n=722)
No
Does elevated hs-cTnT predict all-cause death in elderly inpatients with non-acute coronary syndrome?
Hazard Ratio: 3.01 (95% CI 1.67–5.43)
p-value: p=<0.001
Elevated baseline hs-cTnT in elderly non-ACS inpatients is a strong, independent predictor of long-term all-cause mortality, which is primarily driven by non-cardiovascular deaths.
Supports hs-cTnT-based risk stratification in elderly non-ACS inpatients; hypothesis-generating pending prospective validation.
Objective: Low-level high-sensitivity cardiac troponin T (hs-cTnT) increases in elderly population. In this study, the relationship between hs-cTnT level and all-cause death of elderly inpatients with non-acute coronary syndrome (non-ACS) after discharge from the hospital was investigated. Materials and methods: Non-ACS patients aged >65 years admitted in the General Practice Wards and Department of Geriatrics of Fuxing Hospital Affiliated to Capital Medical University were enrolled in the study. The patients were grouped according to the tertiles of hs-cTnT levels. Biochemical markers, hs-cTnT, and amino-terminal pro-brain natriuretic peptide were measured. The median follow-up period was 47 months, and all-cause deaths of the patients were observed. Results: A total of 722 patients, including 473 males and 249 females, aged 65–98 (82.43±5.98) years were enrolled in the study. The level of hs-cTnT was found to be higher in males, and increased with age and comorbidities ( P <0.01). Compared with low-level group, NT-proBNP level of patients in high-level group was higher, while hemoglobin (Hb), estimated glomerular filtration rate (eGFR), and left ventricular ejection fraction (LVEF) levels were lower ( P <0.001). The mortality rate increased significantly with increased hs-cTnT levels ( P <0.001). The total number of deaths was 136 (18.8%), and of these, 108 (79.4%) were noncardiac deaths. Risk of all-cause deaths in the highest hs-cTnT level group was 7.3 times higher than that of the lowest hs-cTnT level group (95% CI: 4.29–12.51, P <0.001). After adjusting for gender, age, comorbidities, NT-proBNP, Hb, eGFR, and LVEF, hs-cTnT level still affected the patient’s survival time (HR: 3.01, 95% CI: 1.67–5.43, P <0.001). Conclusion: These findings suggest that low-level hs-cTnT was increased in elderly inpatients without ACS. They further highlight that baseline hs-cTnT level was associated with increased risk of all-cause deaths among patients after their discharge, and most deaths were from non-cardiovascular diseases.
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Wu et al. (2018) conducted a cohort in non-acute coronary syndrome (n=722). High-sensitivity cardiac troponin T (hs-cTnT) level vs. Lowest hs-cTnT level group was evaluated on All-cause death (HR 3.01, 95% CI 1.67-5.43, p=<0.001). Higher baseline hs-cTnT levels in elderly inpatients with non-acute coronary syndrome were associated with an increased risk of all-cause death (adjusted HR 3.01; 95% CI 1.67-5.43; P<0.001).
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