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October 1, 1997Journal of Neurology Neurosurgery & PsychiatryOpen Access

Left ventricular dysfunction: a clue to cognitive impairment in older patients with heart failure

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Key result

Left ventricular ejection fraction was independently associated with cognitive performance (MMSE score) in older patients with chronic heart failure (beta=0.58; P=0.001).

Why the study?

Is lower left ventricular ejection fraction associated with cognitive impairment in older patients with chronic heart failure?

Population

57 consecutive older patients with mild to moderate chronic heart failure, mean age 76.7 years

Design

Cross-sectional

Authors

GZGiuseppe ZuccalàUniversità Cattolica del Sacro CuoreCCCaterina CattelUniversità Cattolica del Sacro CuoreEMEster Manes-GravinaAgostino Gemelli University Polyclinic

Discussion

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Implication

LV dysfunction may flag cognitive risk in older HF; leaves open need for prospective screening trials.

Key Points

  • This study aims to assess the prevalence and factors contributing to cognitive dysfunction in older patients with heart failure.
  • Cross-sectional study of 57 patients with chronic heart failure, mean age 76.7 years.
  • Assessment included physical exams, blood tests, ECG, echocardiography, and several cognitive tests.
  • Cognitive performance evaluated using the Mini Mental State Examination (MMSE) and depression scales.
  • 53% of participants had MMSE scores <24 indicating cognitive impairment.
  • Lower cognitive scores were significantly correlated with left ventricular ejection fractions ≤30%.
  • Regression analysis showed that both age and left ventricular ejection fraction were significantly associated with MMSE scores.

Study Design

Type

Cross-Sectional (n=57)

Structured PICO

Is lower left ventricular ejection fraction associated with cognitive impairment in older patients with chronic heart failure?

P
Population
57 older patients (mean age 76.7 years) with chronic heart failure assessed for cognitive dysfunction 24 hours before hospital discharge.
O
Outcome
Cognitive dysfunction assessed by mini mental state examination (MMSE) score

Main Result

Effect estimate: beta 0.58

p-value: p=0.001

Cite This Study

Zuccalà et al. (1997) conducted a cross-sectional in chronic heart failure (n=57). Left ventricular ejection fraction was evaluated on MMSE score (beta 0.58, p=0.001). Left ventricular ejection fraction was independently associated with cognitive performance (MMSE score) in older patients with chronic heart failure (beta=0.58; P=0.001).

synapsesocial.com/papers/6a5f84a843fbe6fe485ff08fhttps://doi.org/10.1136/jnnp.63.4.509

Topics

Heart failureHFrEF treatment
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Also Consider

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