Key result
A 105-km mountain ultra-marathon significantly increased cardiac biomarkers immediately post-race, including hsTnT from 7.6 to 31.7 ng/L (p<0.0001), with most returning to baseline within 7 days.
Why the study?
Participation in ultra-marathons is growing, but data regarding the impact of this exercise on the cardiovascular system remain contradictory.
Does participating in a mountain ultra-marathon alter cardiac and inflammatory biomarkers in ultra-trail runners?
Observational (n=28)
Does participating in a mountain ultra-marathon alter cardiac and inflammatory biomarkers in ultra-trail runners?
Absolute Event Rate: 31.7% vs 7.6%
p-value: p=<0.0001
Ultra-marathon running induces significant increases in cardiac and inflammatory biomarkers that can persist for at least 7 days post-race.
Acute biomarker rises post-ultra-marathon warrant cautious interpretation; leaves open long-term CV implications.
The number of participants in ultra-marathons is increasing. However, the data regarding the impact of this type of exercise on the cardiovascular system are contradictory. In our study, 28 ultra-trail runners were enrolled. Blood samples were collected at three time points: immediately before, immediately after, and 7 days after the ultra-marathon. Different biomarkers were measured. Immediately after the race, the blood concentrations of the different cardiac and inflammatory biomarkers increased significantly. Interestingly, some biomarkers remained high even after 7 days of recovery.
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Goff et al. (2022) conducted an observational in Healthy ultra-marathon runners (n=28). 105-km mountain ultra-marathon vs. Baseline (pre-race) was evaluated on High-sensitivity troponin T (hsTnT) concentration (ng/L) (p=<0.0001). A 105-km mountain ultra-marathon significantly increased cardiac biomarkers immediately post-race, including hsTnT from 7.6 to 31.7 ng/L (p<0.0001), with most returning to baseline within 7 days.
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