Key result
Statin use at hospital discharge was associated with a significantly lower risk of new-onset atrial fibrillation after acute myocardial infarction (HR 0.935).
Why the study?
The association between AF and serum lipid profiles is unclear, and whether statin use lowers the incidence of new-onset AF after AMI remains controversial.
Does statin use reduce new-onset atrial fibrillation in patients with acute myocardial infarction?
Cohort (n=27,553)
Yes
Does statin use reduce new-onset atrial fibrillation in patients with acute myocardial infarction?
Hazard Ratio: 0.935 (95% CI 0.877–0.998)
p-value: p=0.0427
Statin therapy following acute myocardial infarction is associated with a modestly reduced risk of developing new-onset atrial fibrillation.
Statin use was associated with lower post-AMI AF; leaves open whether RCTs would confirm benefit or alter practice.
Atrial fibrillation (AF) is an important complication of acute myocardial infarction (AMI). The association between AF and serum lipid profile is unclear and statin use for lowering the incidence of new-onset AF remains controversial. The objective of this study was to investigate whether statins confer a beneficial effect on AF after AMI.Data available in the Taiwan National Health Insurance Research Database on 32886 AMI patients between 2008 and 2011 were retrospectively analyzed. Total 27553 (83.8%) had complete 1-yr follow-up data. Cardiovascular outcomes were analyzed based on the baseline characteristics and AF type (existing, new-onset, or non-AF). AF groups had significantly higher incidence of heart failure (HF), stroke, all-cause death, and major adverse cardiac and cerebrovascular event (MACCE) after index AMI (all P < .05). In contrast, myocardial re-infarction (re-MI) was not significantly different among the three groups (P = .95). Statin use tended to be associated with lower risk of new-onset AF after AMI (HR: 0.935; 95% confidence interval (CI): 0.877-0.998; P = .0427).Existing AF and new-onset AF subgroups had similar cardiovascular outcomes after AMI and were both inferior to the non-AF group. Statin tended to reduce new-onset AF after AMI.
No takes yet. Share an insight, caveat, or question.
Tseng et al. (2020) conducted a cohort in Acute myocardial infarction (AMI) (n=27,553). Statin use vs. No statin use was evaluated on New-onset atrial fibrillation (HR 0.935, 95% CI 0.877-0.998, p=0.0427). Statin use at hospital discharge was associated with a significantly lower risk of new-onset atrial fibrillation after acute myocardial infarction (HR 0.935).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: