Key result
Transgenic upregulation of IK1 in mice led to multiple abnormalities of cardiac excitability, including slowed heart rate, premature ventricular contractions, AV block, and atrial fibrillation.
Transgenic upregulation of IK1 in mice leads to significant adverse effects on cardiac electrical activity, including shortened action potential duration, short Q-T interval, and arrhythmias.
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Provides first TG mouse model for IK1 studies; leaves open human disease relevance.
Li et al. (2004) studied Cardiac excitability abnormalities. Transgenic upregulation of IK1 (Kir2.1 expression) was evaluated on Cardiac excitability and electrical activity. Transgenic upregulation of IK1 in mice led to multiple abnormalities of cardiac excitability, including slowed heart rate, premature ventricular contractions, AV block, and atrial fibrillation.
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