Why the study?
Does the expression of human I(Ks) channels alter electrophysiological properties and beta-adrenergic sensitivity in the adult murine heart?
Population
Adult mice (transgenic mice expressing human delayed rectifier K cardiac current (I) channels and wild-type…
Comparison
Expression of human I channels and infusion of… vs Wild-type mice (WT) lacking native I(Ks)
Design
Preclinical
Authors
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Human I(Ks) expression heightens arrhythmia susceptibility in murine models; leaves open translation to human electrophysiology and beta-adrenergic responses.
Does the expression of human I(Ks) channels alter electrophysiological properties and beta-adrenergic sensitivity in the adult murine heart?
Expression of human I(Ks) channels in murine hearts imparts beta-adrenergic sensitivity to the ventricles and increases susceptibility to ventricular tachyarrhythmias.
Tracy et al. (2003) studied this question.