Key result
Cardiac HERG expression cuts inducible atrial tachyarrhythmias ~75% vs wild-type in mice.
Why the study?
The impact of HERG current (I(Kr)) on the incidence of cardiac arrhythmias was investigated using a transgenic mouse model expressing human HERG in the heart.
Does HERG expression in the mouse heart prevent experimentally induced arrhythmias in a transgenic mouse model?
Population
Transgenic mice expressing human HERG in the heart and wild-type mice
Comparison
Transgenic HERG expression vs wild-type mice
Design
Preclinical experimental study
Authors
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HERG overexpression may confer anti-arrhythmic protection in mice; hypothesis-generating for channel-targeted therapies with no clinical implications yet.
Does HERG expression in the mouse heart prevent experimentally induced arrhythmias in a transgenic mouse model?
Absolute Event Rate: 18.2% vs 73.3%
Expression of human ERG K+ channels in the mouse heart exerts a protective anti-arrhythmic effect in vivo.
Royer et al. (2004) studied Cardiac arrhythmias. Expression of human ERG K channels (HERG) vs. Wild-type (WT) mice was evaluated on Induction of atrial tachyarrhythmias by atrial pacing. Transgenic mice expressing HERG in the heart were protected against experimental induction of atrial tachyarrhythmias compared to wild-type mice (18.2% vs 73.3% inducible).
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