Key result
Expression of constitutively activated rac1 in the myocardium of transgenic mice induced a lethal dilated cardiomyopathy in neonates and a transient cardiac hypertrophy in juvenile mice, associated with altered focal adhesion regulation.
Population
Transgenic mice expressing constitutively activated rac1 specifically in the myocardium
Design
Preclinical
Authors
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Rac1 activation induces cardiomyopathy in mice; leaves open whether targeting this pathway affects human cardiac disease.
In vivo activation of rac1 in the myocardium demonstrates that dilation and hypertrophy can share a common molecular origin related to focal adhesion reorganization.
Sussman et al. (2000) studied Cardiomyopathy. Constitutively active rac1 expression vs. Non-transgenic control mice was evaluated on Development of cardiomyopathic phenotypes. Expression of constitutively activated rac1 in the myocardium of transgenic mice induced a lethal dilated cardiomyopathy in neonates and a transient cardiac hypertrophy in juvenile mice, associated with altered focal adhesion regulation.
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