Key result
Lepirudin provided effective anticoagulation during cardiopulmonary bypass in a patient with heparin allergy, but resulted in severe postoperative coagulopathy and excessive blood loss.
Why the study?
Does lepirudin provide safe and effective anticoagulation during cardiopulmonary bypass in patients with heparin allergy?
Case Report (n=1)
Does lepirudin provide safe and effective anticoagulation during cardiopulmonary bypass in patients with heparin allergy?
Lepirudin can provide effective anticoagulation for cardiopulmonary bypass in patients with heparin allergy, but strict ECT monitoring is required to prevent post-operative hemorrhage.
Alerts clinicians to bleeding risks with lepirudin in CPB; leaves open safer alternatives for heparin-allergic patients.
A treatment strategy of a difficult and unusual problem is presented. We are reporting a case of a patient who had a documented allergy to heparin and required Cardiac surgery for an ASD closure. The anticoagulation regime used during cardiopulmonary bypass was lepirudin based. This report indicates that r-hirudin provides effective anticoagulation, however unless ECT is monitoring, post operative hemorrhage is encountered. Therefore this case is unique not only because of its rarity but also by the fact that it presents the caveats encountered when ECT is not available.
No takes yet. Share an insight, caveat, or question.
Haralabos Parissis (2011) conducted a case report in Heparin allergy requiring cardiopulmonary bypass (n=1). Lepirudin was evaluated on Anticoagulation efficacy and postoperative blood loss. Lepirudin provided effective anticoagulation during cardiopulmonary bypass in a patient with heparin allergy, but resulted in severe postoperative coagulopathy and excessive blood loss.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: