Key result
r-hirudin (lepirudin) was successfully used for cardiopulmonary bypass in a 67-year-old man with heparin-induced thrombocytopenia type II.
Case Report (n=1)
Lepirudin can be successfully used and monitored during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II.
Supports lepirudin for CPB in HIT II; hypothesis-generating and should not yet change practice.
We report the successful use of r-hirudin (lepirudin) for cardiopulmonary bypass in a 67-year-old man who developed heparin-induced thrombocytopenia type II during heparin treatment of an extensive deep venous thrombosis. Lepirudin was monitored by the modified ecarin clotting time in a "mobile laboratory" set up next to the cardiac theatre, aiming for lepirudin levels of 3.5 to 4.5 microg/ml during bypass.
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Manikappa et al. (2005) conducted a case report in Heparin-induced thrombocytopenia type II (n=1). r-hirudin (lepirudin) was evaluated on Successful use for cardiopulmonary bypass. r-hirudin (lepirudin) was successfully used for cardiopulmonary bypass in a 67-year-old man with heparin-induced thrombocytopenia type II.
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