Key result
Type 2 diabetes was more frequent in women than men with STEMI (28% vs 16.6%, P<0.0001) and was a significant independent risk factor for in-hospital and 1-year mortality in women.
Why the study?
Does type 2 diabetes worsen the clinical course and prognosis in women with STEMI?
Observational (n=26,035)
Yes
Does type 2 diabetes worsen the clinical course and prognosis in women with STEMI?
Type 2 diabetes is a significant independent risk factor for mortality in women with STEMI, who experience worse outcomes and receive less frequent primary PCI compared to other groups.
Diabetes signals higher STEMI mortality risk in women; leaves open whether sex-specific strategies improve outcomes.
OBJECTIVE: To evaluate the effect of type 2 diabetes on the clinical course and prognosis of women with ST-segment elevation myocardial infarction (STEMI) and diabetes. RESEARCH DESIGN AND METHODS: A total of 26,035 consecutive patients with STEMI who were hospitalized in 456 hospitals in Poland during 1 year were analyzed. The data were obtained from the Polish Registry of Acute Coronary Syndromes (PL-ACS). RESULTS: Type 2 diabetes occurred more frequently in women than in men (28 vs. 16.6%; P < 0.0001). The proportion of women was larger among patients with diabetes (47.1 vs. 31.3%; P < 0.0001), and compared with women without diabetes, diabetic women had worse clinical profiles. Women with diabetes were most frequently treated conservatively. Both women and men with diabetes had significantly more advanced atherosclerotic lesions than women without diabetes. Women with diabetes had the highest in-hospital, 6-month, and 1-year mortality rates. Multivariate analysis indicated that type 2 diabetes was a significant independent risk factor for in-hospital and 1-year mortality in women with STEMI. Primary percutaneous coronary intervention (pPCI) was a significant factor associated with the decreased 1-year mortality in women without diabetes. CONCLUSIONS: Type 2 diabetes was a significant independent risk factor for in-hospital and 1-year mortality in women with STEMI. Women with diabetes had the poorest early and 1-year prognoses after STEMI when compared with women without diabetes and men with diabetes. Although pPCI improves the long-term prognosis of women with diabetes, it is used less frequently than in women without diabetes or men with diabetes.
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Radomska et al. (2013) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=26,035). Type 2 diabetes vs. Without diabetes / Men with diabetes was evaluated on In-hospital and 1-year mortality. Type 2 diabetes was more frequent in women than men with STEMI (28% vs 16.6%, P<0.0001) and was a significant independent risk factor for in-hospital and 1-year mortality in women.
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