Key result
The ACE gene DD and ID genotypes, and the D allele, were significantly more frequent in patients with androgenetic alopecia compared to healthy controls (p < 0.05).
Why the study?
Although the ACE gene I/D polymorphism plays a role in multiple inflammatory disorders, no studies had investigated its association with androgenetic alopecia susceptibility.
Is the ACE gene I/D polymorphism associated with increased susceptibility to androgenetic alopecia in Egyptian patients?
Case-Control (n=200)
Is the ACE gene I/D polymorphism associated with increased susceptibility to androgenetic alopecia in Egyptian patients?
The ACE gene I/D polymorphism may serve as a genetic susceptibility indicator for androgenetic alopecia development in Egyptian patients.
Answers are grounded in this paper and cite their sources.
ACE D allele was associated with AGA risk in Egyptians; leaves open whether genotyping aids prediction or management beyond this cohort.
BACKGROUND: Androgenetic alopecia (AGA) is a prevalent condition with a complex etiopathogenesis. Angiotensin-converting enzyme (ACE) gene located on the chromosome 17q23 contains an insertion (I) and deletion (D) polymorphism in the intron 16. This gene polymorphism plays a role in multiple inflammatory disorders. However, there are no studies investigating its association with AGA susceptibility. OBJECTIVES: In this work, we aimed at exploring the association of ACE gene I/D polymorphism in AGA susceptibility in a group of Egyptian patients. METHODS: This study included 100 AGA patients, and 100 apparently healthy controls. The ACE gene I/D polymorphism was analyzed by polymerase chain reaction. RESULTS: The DD, ID genotypes, and D allele showed higher frequent distribution among studied AGA patients than controls (p < 0.05 each). Positive family history and ACE gene I/D polymorphism were considered AGA susceptibility predictors in both uni- and multivariable analyses [p < 0.05 each (OR (95% CI)] on applying logistic regression analysis for risk factors prediction. CONCLUSIONS: This study highlights the possible contribution of the suspected genetic polymorphism as a susceptibility indicator for AGA development in the examined group of patients.
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Mustafa et al. (2021) conducted a case-control in Androgenetic alopecia (n=200). ACE gene I/D polymorphism vs. Healthy controls was evaluated on Androgenetic alopecia susceptibility (p=<0.05). The ACE gene DD and ID genotypes, and the D allele, were significantly more frequent in patients with androgenetic alopecia compared to healthy controls (p < 0.05).
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