Key result
The angiotensin-converting enzyme gene ID genotype was significantly more frequent in Egyptian patients with myocardial infarction compared to healthy controls (62.0% vs. 47.5%, p<0.05).
Why the study?
Is the angiotensin-converting enzyme gene I/D polymorphism associated with myocardial infarction in Egyptian patients?
Population
317 Egyptian individuals, comprising 79 myocardial infarction cases and 238 healthy unrelated individuals of…
Comparison
Angiotensin-converting enzyme gene… vs Healthy controls / II genotype
Design
Case-control
Authors
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Supports ACE ID-MI link in Egyptians; hypothesis-generating requiring prospective validation before clinical use.
Case-Control (n=317)
Is the angiotensin-converting enzyme gene I/D polymorphism associated with myocardial infarction in Egyptian patients?
Absolute Event Rate: 62% vs 47.5%
p-value: p=<0.05
The ACE gene I/D polymorphism, particularly the ID genotype, is associated with an increased risk of myocardial infarction in Egyptian patients.
Settin et al. (2009) conducted a case-control in Myocardial infarction (n=317). Angiotensin-converting enzyme gene insertion/deletion (I/D) polymorphism vs. Healthy controls was evaluated on Frequency of ID genotype (p=<0.05). The angiotensin-converting enzyme gene ID genotype was significantly more frequent in Egyptian patients with myocardial infarction compared to healthy controls (62.0% vs. 47.5%, p<0.05).