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Demonstrates effective synthesis of trisulfides with diverse functionalities, indicating broader applications for sensitive compounds.
An acid-mediated synthesis of unsymmetrical trisulfides has been developed. Disulfides bearing a 4,4’-dimethoxydiphenylmethyl group were efficiently converted into the corresponding trisulfides using an acid additive, a hydrosilane, and a sulfur electrophile. This protocol enables the synthesis of trisulfides incorporating a wide range of substituents, including functionalities sensitive to basic conditions, providing a complementary approach to existing base-mediated sulfur-elongation strategies.
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Inokuma et al. (2026) studied this question.
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