TfOH-Mediated Synthesis of Unsymmetrical Disulfides from Diethyl 2,2’-Disulfanediylbis(4-methyl-6-phenylpyrimidine-5-carboxylate)

A novel approach for the S–S bond exchange reaction of two symmetrical disulfides, promoted by TfOH under metal-free conditions at room temperature, has been developed. This protocol facilitates the efficient and effortless synthesis of a series of important unsymmetrical disulfides with yields of up to 93% and excellent functional group compatibility. The advantages of this strategy include straightforward operation, broad substrate scope, good functional group tolerance, high chemoselectivity, and the ability to operate under ambient conditions.