A new method synthesizes unsymmetrical diaryl disulfides using sodium sulfinates and arenediazonium tetrafluoroborates, suggesting mild conditions.
A facile transition-metal- and base-free strategy has been explored for the synthesis of unsymmetrical (het)aryl disulfides from easily accessible sulfinate salts, sodium metabisulfite, and arenediazonium tetrafluoroborates using I2/DMF as a reducing agent. The method exploits the scarce use of sodium metabisulfite as a divalent sulfur source for the creation of S-S bond, and is endowed with good substrate scope.
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Rai et al. (2025) studied this question.
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