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July 20, 2026The Journal of Organic Chemistry

Visible-Light Photoredox-Catalyzed Radical Addition/Double Cyclization of Indole with Alkenes: Access to gem-Difluorotetrahydrocarbazolones

Zhen Yao Yuanyuan Wang Lifang Qi Jing Guan Youping Tian Bowen Pan Xiongwei LIU

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Key Points

This research aims to develop an effective method for synthesizing gem-difluorotetrahydrocarbazolones via photoredox catalysis.
Utilized visible-light photoredox catalysis to promote radical addition and double cyclization.
Applied a specific complex as the primary photocatalyst for the reaction.
Employed various alkenes to assess the broad applicability of the method.
Successfully synthesized gem-difluorotetrahydrocarbazolones through the outlined catalytic process.
Demonstrated the efficiency and effectiveness of the photocatalyst in various conditions.

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Implication

Demonstrates effective cyclization of indole with alkenes, suggesting a new synthetic pathway.

Abstract

] complex served as the key photocatalyst for this transformation.

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Cite This Study

Yao et al. (2026) studied this question.

synapsesocial.com/papers/6a605dfa4163e025518d7d66 https://doi.org/10.1021/acs.joc.6c00966

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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