Construction of gem-difluoroalkenyl indoles via photoinduced Fukuyama-type cyclization of isocyanides

Jingxuan Zhang; Haixia Zhao; Yue Pu; Kaijie Tang; He Chen; Qihang Huang; Chen Chen; Jian Wang

doi:10.1039/d6cc01526c

January 1, 2026Chemical Communications

Construction of gem-difluoroalkenyl indoles via photoinduced Fukuyama-type cyclization of isocyanides

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Key Points

The aim is to develop an efficient method for synthesizing gem-difluoroalkenyl indoles via cyclization.
Photoinduced Fukuyama-type cyclization of trifluoromethyl alkene decorated phenyl isocyanides.
Utilization of various radical precursors including alkyl, sulfur, and phosphonyl radicals.
Successful synthesis of gem-difluoroalkenyl indoles through the described cyclization process.
Demonstrated efficiency with different alkyl radical precursors.

Implication

Demonstrates efficient synthesis of gem-difluoroalkenyl indoles, suggesting new pathways for chemical synthesis.

Abstract

Efficient access to gem-difluoroalkenyl indoles through cyclization of trifluoromethyl alkene decorated phenyl isocyanides with alkyl (Me, 1o, 2o, 3o), sulfur and phosphonyl radical precursors has been developed. The imidoyl radical...

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69eb0cb2553a5433e34b5a87 https://doi.org/10.1039/d6cc01526c

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Construction of gem-difluoroalkenyl indoles via photoinduced Fukuyama-type cyclization of isocyanides

Key Points

Implication

Abstract

Discussion

Cite This Study

Construction of gem-difluoroalkenyl indoles via photoinduced Fukuyama-type cyclization of isocyanides

Key Points

Implication

Abstract

Discussion

Cite This Study

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