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April 24, 2026Chemical Communications0 citations

Construction of gem-difluoroalkenyl indoles via photoinduced Fukuyama-type cyclization of isocyanides

JZJingxuan ZhangAnhui Normal UniversityHZHaixia ZhaoAnhui Normal UniversityYPYue PuAnhui Normal University

Key Points

  • The aim is to develop an efficient method for synthesizing gem-difluoroalkenyl indoles via cyclization.
  • Photoinduced Fukuyama-type cyclization of trifluoromethyl alkene decorated phenyl isocyanides.
  • Utilization of various radical precursors including alkyl, sulfur, and phosphonyl radicals.
  • Successful synthesis of gem-difluoroalkenyl indoles through the described cyclization process.
  • Demonstrated efficiency with different alkyl radical precursors.

Abstract

Efficient access to gem-difluoroalkenyl indoles through cyclization of trifluoromethyl alkene decorated phenyl isocyanides with alkyl (Me, 1o, 2o, 3o), sulfur and phosphonyl radical precursors has been developed. The imidoyl radical...

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Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69eb0cb2553a5433e34b5a87https://doi.org/10.1039/d6cc01526c
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