Cardiovascular Risk Reclassification With the 2026 Dyslipidemia Guideline
Key result
PREVENT-ASCVD equations reclassify cardiovascular risk compared to 2013 PCEs.
Why the study?
To evaluate the extent of cardiovascular risk reclassification from the 2013 pooled cohort equations (PCEs) to the 2023 Predicting Risk of Cardiovascular EVENTs (PREVENT-ASCVD) equations.
Does the 2023 PREVENT-ASCVD equation alter cardiovascular risk classification compared to the 2013 pooled cohort equations in the NHANES population?
Key Points
- The aim is to assess how the new 2023 PREVENT-ASCVD equations alter cardiovascular risk classification compared to the 2013 PCEs.
- Used data from the National Health and Nutrition Examination Survey (NHANES).
- Evaluated risk reclassification based on changes in predictive equations.
- Identified significant differences in cardiovascular risk assessments using PREVENT-ASCVD compared to PCEs.
Structured PICO
Does the 2023 PREVENT-ASCVD equation alter cardiovascular risk classification compared to the 2013 pooled cohort equations in the NHANES population?
P
Population
Participants from the National Health and Nutrition Examination Survey (NHANES)
I
Intervention
2023 Predicting Risk of Cardiovascular EVENTs (PREVENT-ASCVD) equations
C
Comparator
2013 pooled cohort equations (PCEs)
O
Outcome
Extent of cardiovascular risk reclassification
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Key expert perspectives
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“Notably, there was no significant net change in statin recommendation, suggesting that risk recalibration with PREVENT-ASCVD does not translate into fewer people recommended for evidence-based preventive therapy at the population level.”
“I think it's going to be interesting to see what [the] public response is to the idea [that] we're basically recommending anybody over the age of 70 should be on a statin. Is that overkill?”
“The shift to a longer view of cardiovascular disease risk is a sea change for doctors in counseling patients.”
Implication
Evaluates cardiovascular risk reclassification using updated equations, indicating stronger predictions for health outcomes.
Abstract
This study uses data from the National Health and Nutrition Examination Survey (NHANES) to evaluate the extent of cardiovascular risk reclassification from the 2013 pooled cohort equations (PCEs) to the 2023 Predicting Risk of Cardiovascular EVENTs (PREVENT-ASCVD) equations.
Coverage & sources
Journal, society, and media accounts. Useful signal, not independent expert judgment.
Discussion
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Cite This Study
Peng et al. (2026) studied this question. The 2023 PREVENT-ASCVD equations were evaluated to determine the extent of cardiovascular risk reclassification compared to the 2013 pooled cohort equations.