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T HE therapeutic value of the nitrogen mustards in the palliative treatment of Hodgkin's disease, lymphosarcoma, leukemia, and allied disorders has been established by numerous publications in the past two years.l*3-7* lo* l 2 ~ Is Other types of cancer have been treated much less extensively with the nitrogen mustards, largely because the results, in the occasional cases reported, have not bem impres~ive.~~In the course of our study of the effects of the nitrogen mustards on various types of neoplastic disease, we obtained a remarkable temporary remission in' a patient with an anaplastic carcinoma of the lung.1°This observation prompted the more extensive trial of the nitrogen mustards in primary lung carcinoma, and our results form the basis for this report.Our therapeutic experiences with several other types of From Memorial Hospital, New York, N. Y.
Karnofsky et al. (Mon,) studied this question.